Brain Development in Early Childhood

By The Preston Robert Tisch Brain Tumor Center

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When we talk about early childhood brain development, most of us imagine crawling babies, colorful toys, and milestones like first words or first steps. But at The Preston Robert Tisch Brain Tumor Center at Duke, we often meet families where this development journey takes an unexpected turn. 

If you're a parent navigating a child’s brain tumor diagnosis or someone just trying to understand what’s happening inside your little one’s growing mind, we’re here to help. Let’s break down what’s happening inside a developing brain and how pediatric brain cancer can change the path.

brain development in early childhood

What Happens in the Brain During Early Childhood?

Between birth and age five, a child’s brain develops faster than at any other time in life. In fact, 90% of brain growth happens before kindergarten. The brain builds more than a million neural connections every second. These connections shape how your child thinks, moves, speaks, and responds to the world. During this window, the foundation for lifelong learning, behavior, and health is built.

But what happens when a brain tumor enters the picture?

Brain tumors in children can affect how and when these neural pathways form. Depending on the tumor’s location and size, it may interfere with motor skills, memory, language, or emotional regulation. Treatments like surgery, radiation, or chemotherapy can also impact development. That’s why timing, support, and specialized care matter so much.

Why Are Ages 0 to 3 So Important for Brain Development?

From birth to age three, the brain is like a sponge, absorbing everything. These early years set the stage for how your child will learn and connect with others. Even small interactions like eye contact, singing, or playing peek-a-boo help strengthen important brain circuits.

These early developmental cues may look different in children with brain tumors. Fatigue, treatment side effects, or neurological symptoms might slow down a child's engagement. But the need for stimulation, connection, and care doesn’t go away; it just requires a little more creativity and patience.

🧠 Tisch Tip: If your child is in treatment, try small sensory-friendly activities like story time with soft lighting, gentle music, or simply holding hands and talking. These moments count.

early childhood brain development

What Can Disrupt or Delay Brain Development?

For children without a medical diagnosis, things like malnutrition, chronic stress, or environmental toxins can hinder brain growth. In children with brain tumors, however, disruptions can be more direct:

  • Tumor location: A frontal lobe tumor may delay executive functions like impulse control or emotional regulation. A tumor near the cerebellum could affect coordination or balance.
     
  • Treatment impact: Some therapies can temporarily affect memory, attention, or energy levels.
     
  • Medical stress: Frequent hospital visits, separation from peers, and physical discomfort can all make learning and development harder.

Neuroplasticity, your child’s brain’s ability to adapt, is on your side. With the right support, even a challenged brain can find new paths.

What Boosts Brain Development, Even During Illness?

At Duke’s Tisch Brain Tumor Center, we lean into a full-circle approach: treating the tumor and supporting the brain’s overall well-being. Here’s what we recommend:

1. Consistent, Loving Interaction

Even if your child is tired or less responsive, keep talking, cuddling, and engaging. It builds trust and stimulates essential circuits.

2. Therapies That Target Development

Our neuro-oncology team works alongside pediatric therapists to personalize care. From speech therapy to occupational therapy, early interventions help kids meet milestones on their own timeline.

3. Nutrition

Feeding the brain matters. Our team includes diet and nutrition experts who help families choose brain-healthy foods, even when appetite is low due to treatment.

4. Play

Play is essential. Toys, music, art, and movement all contribute to developmental gains. We help families find play that works, even during inpatient stays.

5. Restorative Sleep

Sleep is when the brain does a lot of its organizing work. We help families create soothing sleep routines, even in the hospital setting.

Recognizing the Signs: What If Brain Development Is Delayed?

Every child is different, and development doesn’t follow a straight line. But if you notice any of these symptoms, especially in a child with a brain tumor, it’s worth speaking with your care team:

  • Lack of interest in interaction or play
     
  • Delayed speech or difficulty with words
     
  • Struggles with balance or movement
     
  • Trouble focusing or following instructions
     
  • Emotional outbursts or mood changes that are not typical for their age

Early intervention is key, and at Tisch, we don’t wait to take action. If something feels off, we explore it together.

The Tisch Brain Tumor Center at Duke: Supporting More Than Just the Diagnosis

We know brain tumors in children don’t just affect the body; they shift the entire family’s reality. That’s why we offer integrative care that includes:

  • Pediatric neuro-oncology specialists
     
  • Developmental pediatricians and therapists
     
  • Child Life Services to support emotional health
     
  • Resources to help with school accommodations and long-term care planning

We don’t just treat tumors. We care for the whole child—and the whole family.

Interested in exploring therapy support or educational planning? Connect with our pediatric neuro-oncology team.

Duke Is Your Partner in Every Step Forward

Early childhood is a critical time, but it doesn’t come with a script. Especially not when you’re navigating a diagnosis as serious as a brain tumor. At The Preston Robert Tisch Brain Tumor Center at Duke, we’re here to help families make sense of the uncertainty and build a future where your child can thrive, one small milestone at a time.

👉 Explore our Adult Neuro-Oncology Program
👉 Schedule a consultation
👉 Read more on our blog

Related Readings:

FAQs: Brain Development and Brain Tumors in Children

1. Why is 0 to 3 years important?

This adds depth to the conversation around early brain plasticity and why those years are especially critical, even more so for children affected by brain tumors.

2. What are the symptoms of an underdeveloped brain?

While similar to delayed development, this allows for a more defined answer around clinical or observable symptoms, especially in the context of medical evaluation.

3. What boosts brain development?

Perfect to tie in therapy, nutrition, caregiver interaction, and the role of Duke’s pediatric specialists.

4. What causes a baby's brain to not develop properly?

This can highlight prenatal factors, congenital issues, or early-life stressors, which is useful for early-intervention messaging.

5. What is the most common brain disorder in children?

This provides a broader medical context and can acknowledge brain tumors while distinguishing them from other neurological issues like epilepsy or ADHD.


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