What is Chemotherapy?

By The Preston Robert Tisch Brain Tumor Center

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Chemotherapy is a critical component of cancer treatment, yet many people have questions about what it entails and how it works. In this article, we will dive into the world of chemotherapy, providing you with valuable insights and answers to common questions. Whether you or a loved one is considering chemotherapy or you simply want to learn more about this medical procedure, this article will serve as your go-to resource.

Chemotherapy, often referred to as "chemo," is a medical treatment that uses powerful drugs to target and destroy cancer cells. It's a cornerstone in the fight against brain cancer and is administered in various forms, including oral medications and intravenous injections.

Understanding The Basics 

The history of chemotherapy is fascinating. It traces its roots back to the early 20th century when researchers began experimenting with chemicals to combat cancer. The breakthrough came in the 1940s, when the first chemotherapy drug, nitrogen mustard, was developed. Since then, chemotherapy has evolved significantly, with numerous drugs and treatment strategies being developed.

Chemotherapy: When Is It Used? 

Chemotherapy is employed in various scenarios:

  • Primary Treatment: In some cases, chemotherapy is the main treatment for cancer, especially when surgery or radiation therapy isn't an option.

 

  • Adjuvant Treatment: After surgery or radiation therapy, chemotherapy may be used to kill any remaining cancer cells and prevent recurrence.

 

  • Neoadjuvant Treatment: Sometimes, chemotherapy is given before surgery or radiation therapy to shrink tumors, making them easier to remove or treat.

 

  • Palliative Care: In advanced stages of cancer, chemotherapy can help manage symptoms and improve the patient's quality of life.

Types of Chemotherapy 

There are different types of chemotherapy drugs, each with its own unique mechanism of action and side effects. Some common categories include:

  • Cytotoxic Drugs: These drugs directly kill cancer cells by interfering with their DNA or other vital processes.

 

  • Targeted Therapy: Targeted drugs focus on specific molecules involved in cancer growth, minimizing harm to healthy cells.

 

  • Immunotherapy: This innovative approach boosts the body's immune system to recognize and attack cancer cells.

What to Expect During Chemotherapy 

Undergoing chemotherapy can be frightening, but knowing what to expect can help ease anxiety. Treatment plans are tailored to each patient's unique circumstances, including the type of cancer and its stage. Chemotherapy sessions are usually scheduled in cycles, with rest periods in between to allow the body to recover.

Common side effects of chemotherapy include nausea, fatigue, hair loss, and changes in blood cell counts. However, advances in supportive care are helping to improve the management of these side effects.

Chemotherapy vs. Radiation 

What exactly is the difference between chemotherapy and radiation? While both are powerful tools in the fight against cancer, they differ in several key ways. Let's explore the distinctions between chemotherapy and radiation.

As we mentioned before, chemotherapy involves the use of powerful drugs, either administered orally or through intravenous injections, to target and destroy cancer cells throughout the entire body. These drugs circulate in the bloodstream, making them effective in treating cancer that has spread to different parts of the body. However, because they affect both cancerous and healthy cells, chemotherapy can lead to various side effects.

On the other hand, radiation therapy employs high-energy X-rays or other types of radiation to specifically target and damage cancer cells within a localized area. Unlike chemotherapy, radiation therapy is a localized treatment, focusing solely on the area where the cancer is located. This precision minimizes damage to nearby healthy tissues.

Administration: Chemotherapy vs. Radiation Therapy 

  • Chemotherapy: Chemotherapy can be administered in various settings, including hospitals, clinics, and even at home, depending on the specific drugs and treatment plan. Treatment schedules often involve cycles, allowing the body time to recover between sessions.

 

  • Radiation Therapy: Radiation therapy is typically delivered in specialized facilities, such as radiation oncology centers. Patients usually undergo daily treatments over several weeks, with each session lasting only a few minutes.

Side Effects: Chemotherapy vs. Radiation Therapy 

  • Chemotherapy: Due to its systemic nature, chemotherapy can cause a wide range of side effects, including nausea, vomiting, fatigue, hair loss, and changes in blood cell counts. However, advances in supportive care have significantly improved the management of these side effects.

 

  • Radiation Therapy: Radiation therapy primarily affects the area being treated, leading to localized side effects. These may include skin irritation, fatigue, and, in some cases, long-term effects on nearby tissues or organs.

Brain Tumor Treatment Center 

When it comes to battling brain cancer, finding the right treatment center is crucial. At the Preston Robert Tisch Brain Tumor Center, we are committed to providing world-class care for both adults and children facing the challenges of brain tumors. Our center in Durham, NC, is staffed by a team of highly specialized medical professionals who are leaders in the field of neuro-oncology. 

From neurosurgeons to medical oncologists, radiation oncologists, and pediatric specialists, our experts bring years of experience and a deep understanding of brain tumors. We are at the forefront of research and innovation, constantly striving to improve treatment outcomes for our patients. If you or a loved one is facing a brain cancer diagnosis, we encourage you to reach out to our team at the Preston Robert Tisch Brain Tumor Center. Your journey to hope begins here, where expertise, innovation, and compassion come together to provide the best possible care.

Chemotherapy: Commonly Asked Questions 

Is chemotherapy painful?

Chemotherapy itself is not painful, as it is administered through injections or oral medications. However, some side effects, such as injection site discomfort or muscle pain, may occur.

 

How long does a chemotherapy session take?

The duration of a chemotherapy session varies depending on the drugs used and the treatment plan. Sessions can last from a few minutes to several hours.

 

Can I work during chemotherapy?

Many people continue working during chemotherapy, especially if they can manage their side effects. However, it's essential to discuss this with your healthcare team and employer to make necessary accommodations.

 

Will I lose my hair during chemotherapy?

Hair loss is a common side effect of chemotherapy. However, not all chemotherapy drugs cause hair loss, and it is usually temporary. Wigs, scarves, and hats can help manage this side effect.

 

Can I eat normally during chemotherapy?

Maintaining a balanced diet is crucial during chemotherapy. Your healthcare team can provide dietary guidelines to ensure you get the nutrition you need.

 

Is chemotherapy effective for all types of cancer?

Chemotherapy is effective for many types of cancer, but its success depends on the specific cancer type and stage. Your oncologist will determine the most suitable treatment plan. 

 

What are the side effects of chemotherapy? 

Chemotherapy can have various side effects, which may vary from person to person. Common side effects include nausea, vomiting, fatigue, hair loss, and changes in blood cell counts. However, not everyone experiences all of these side effects, and the severity can often be managed with medications and supportive care provided by your healthcare team.

 

What is adjuvant chemotherapy? 

Adjuvant chemotherapy is a form of chemotherapy given after the primary treatment for cancer, which is typically surgery or radiation therapy. The purpose of adjuvant chemotherapy is to kill any remaining cancer cells that may not be visible but could potentially grow and cause a recurrence. It is a preventive measure to reduce the risk of cancer coming back.

 

What is the next treatment after chemotherapy? 

The next treatment after chemotherapy depends on various factors, including the type and stage of cancer, how well the cancer responds to chemotherapy, and the patient's overall health. Following chemotherapy, the next steps may include additional treatments such as radiation therapy, targeted therapy, immunotherapy, hormone therapy (for certain types of cancer), or surgery if it wasn't performed initially. Your oncologist will determine the most appropriate course of action.

 

What is palliative chemotherapy? 

Palliative chemotherapy is a type of chemotherapy administered to patients with advanced-stage cancer, where the primary goal is not necessarily to cure the cancer but to manage symptoms and improve the patient's quality of life. It aims to alleviate pain, reduce the size of tumors, and slow the progression of the disease. Palliative care focuses on enhancing comfort and providing emotional support to patients and their families during challenging times.


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