
An early question that brain tumor patients and caregivers often ask is, “Will I need surgery?” The idea of brain surgery can feel overwhelming, especially when you're still trying to process a diagnosis. And while surgery is often part of treatment, it’s not the only option.
Let’s examine the non-surgical options for brain tumor treatment and what to expect if you or someone you love is making this decision.

What Are the Non-Surgical Treatment Options for Brain Tumors?
Not every brain tumor needs to be removed with surgery. Some tumors are too small, too deep, or slow-growing enough that other treatments may be safer or more effective. Here's a closer look at what’s possible without surgery:
Radiation Therapy
Radiation uses high-energy beams to damage or destroy tumor cells. It's one of the most common non-surgical treatments for brain tumors and can be used alone or in combination with other therapies.
- Stereotactic Radiosurgery (SRS): Despite the name, this isn’t surgery in the traditional sense. It’s a highly focused form of radiation that precisely targets the tumor with minimal impact on surrounding tissue.
- Proton Therapy: This method delivers proton beams instead of traditional X-rays. It’s especially helpful for pediatric patients or tumors located near critical structures in the brain.
- Cobalt-60 Therapy and LINAC Systems: Both provide precision radiation treatment using different technologies. Your care team will explain which may be right for your specific tumor type.
These therapies are painless, noninvasive, and typically done on an outpatient basis. Some patients receive just one session, while others may need several treatments over days or weeks.
Chemotherapy
Chemotherapy is well known for treating many types of cancer, but it also plays a role in brain tumor care. While it’s not used for every patient, it can be especially helpful for high-grade or aggressive tumors.
There are different types of delivery:
- Systemic chemotherapy (pills or IV) sends medication throughout the body.
- Local delivery targets the tumor directly, reducing side effects elsewhere.
Your care team at Duke will consider your tumor’s genetics, growth rate, and location before recommending chemo.
Steroids
If you’re experiencing symptoms like headaches, vision changes, or nausea, swelling around the tumor may be to blame, not the tumor itself. In those cases, corticosteroids can relieve pressure and reduce inflammation and brain swelling. This can improve symptoms quickly and may even delay the need for more aggressive treatment.
Clinical Trials
One of the benefits of being treated at a center like Duke is access to cutting-edge brain cancer clinical trials. These trials test new therapies, sometimes even before they’re widely available, and may include experimental drugs, immunotherapy, or new radiation techniques.
Participation is always voluntary. If a clinical trial is right for you, your care team will walk you through the risks, benefits, and next steps.
Integrative Therapies
Some patients turn to complementary approaches, like acupuncture, mindfulness, nutrition, and nutrition counseling, alongside traditional medical care. At Tisch, we understand that healing isn’t just physical. We support integrative medicine approaches when they’re safe and grounded in evidence.
We always recommend discussing any alternative therapies with your neuro-oncology team to ensure they won’t interfere with primary treatment.

Is It Possible to Treat a Brain Tumor Without Surgery?
Yes, surgery isn't always necessary, depending on the type, size, location, and behavior of the tumor. In fact, non-surgical approaches may be the first line of defense for some low-grade tumors or those in hard-to-reach areas.
What matters most is having a personalized treatment plan and a team that sees the full picture, not just a scan.
There are many reasons a patient may not be a candidate for surgery:
- The tumor is in a delicate or inoperable area of the brain.
- The tumor is slow-growing and not causing symptoms.
- The patient has other health conditions that make surgery high-risk.
- The tumor has already been treated surgically and has recurred.
That doesn’t mean there’s no hope. It just means we turn to other tools in the toolkit. At Duke, we take a collaborative approach. Neurosurgeons, medical oncologists, radiation specialists, nurses, therapists, and support staff all come together to design a plan that’s tailored to you.
Personalized Brain Tumor Care at Duke
From the latest therapies to the most compassionate care, the Preston Robert Tisch Brain Tumor Center is dedicated to helping you make informed choices about your treatment. Whether surgery is on the table or not, our job is to help you feel supported, respected, and seen.
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Related Readings:
- What to Avoid After Brain Surgery
- Do Brain Tumors Show Up In Blood Work?
- What is the Best Treatment for Brain Cancer: Unraveling the Options
FAQs: Common Questions About Non-Surgical Brain Tumor Treatment
1. How successful are non-surgical treatments for brain tumors?
Success depends on the tumor type and individual factors. Many patients see excellent results with radiation or chemotherapy, especially when guided by a specialized team.
2. Can brain tumors be treated without surgery?
Some tumors can be controlled or even eliminated with non-surgical treatments. Others may be managed long-term like a chronic condition.
3. Are there side effects with non-surgical treatments?
There can be. Side effects can include fatigue, nausea, hair loss, or cognitive changes. But these are closely managed by your care team at Duke.
4. How should I prepare for brain tumor surgery?
Preparation depends on your surgery type, but generally includes meeting with your care team, undergoing pre-surgical testing, reviewing medications, and arranging support for recovery.
5. How fast can a brain tumor grow back after surgery?
It varies. Some aggressive tumors can recur within months, while others may remain stable for years. Ongoing monitoring through imaging and check-ins with your Duke team is key to early detection and treatment planning